|
KMID : 0361420100340030259
|
|
Journal of Korean Academy of Rehabilitation Medicine
2010 Volume.34 No. 3 p.259 ~ p.264
|
|
|
Effects of Continuous Repetitive Transcranial Magnetic Stimulation on Pain Response in Spinal Cord Injured Rat
|
|
Bae Young-Kyung
Hwang Se-Jin
Cho Yun-Woo
Park Hae-Woon
Ahn Sang-Ho
Kang In-Soon
Kim Su-Jeong
Seo Jeong-Min
|
|
|
Abstract
|
|
|
Objective: To investigate the effects of continuous repetitive transcranial magnetic stimulation (rTMS) on pain response in spinal cord injured rat.
Method: Forty Sprague-Dawley rats (200∼250 grams, female) were used. Thoracic spinal cord (T9) was contused using New York University (NYU) spinal cord impactor. Ten gram weight rod was dropped from a height of 25 mm to produce spinal cord contusion model with moderate injury. The animals were randomly assigned to two groups: one exposed to real magnetic stimulation (real-rTMS group) and the other not exposed to magnetic stimulation (sham- rTMS group). rTMS was applied for 8 weeks. To assess the effect of continuous rTMS on below-level pain responses after spinal cord injury (SCI), the hindpaw withdrawal response for thermal stimuli, cold stimuli and mechanical stimuli were compared between two groups.
Results: Behavioral response for pain showed that hindpaw withdrawal response for cold stimuli was reduced significantly from 4 weeks after SCI in real-rTMS group compared with sham group (p＜0.05).
Conclusion: These results suggest that continuous rTMS may have beneficial effects on attenuation of cold allodynia after SCI, and it might be an additional non-invasive therapeutic method in patients with chronic neuropathic pain after SCI. (J Korean Acad Rehab Med 2010; 34: 259-264)
|
|
|
KEYWORD
|
|
|
Repetitive transcranial magnetic stimulation (rTMS), Spinal cord injury, Neuropathic pain, Cold allodynia
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|